Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.40 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 3/20 | 0.37 |
| ▸ | CMA1 | P23946 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.35 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.35 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14333564 | 0.78 | EIF2AK2 (0.41) | EIF2AK2TDP2AHRCMA1MAOB | |
| SCHEMBL548762 | 0.75 | AHR (0.50) | EIF2AK2GAATDP2HDAC3AHR | |
| SCHEMBL259844 | 0.73 | SMYD3 (0.43) | EIF2AK2GAACRBNHDAC3AHR | |
| SCHEMBL28346887 | 0.73 | GAA (0.52) | MAPTEIF2AK2GAACRBNAHR | |
| SCHEMBL10368283 | 0.73 | GRIA1 (0.47) | MAPTEIF2AK2CRBNHDAC3AHR | |
| SCHEMBL1162689 | 0.72 | SMYD3 (0.43) | KDM4EEIF2AK2GAATDP2CRBN | |
| SCHEMBL578508 | 0.71 | SRC (0.57) | MAPTEIF2AK2GAAAHRCMA1 | |
| SCHEMBL152807 | 0.71 | HDAC3 (0.45) | POLBEIF2AK2CRBNHDAC3AHR | |
| SCHEMBL12064436 | 0.70 | AHR (0.42) | EIF2AK2CRBNHDAC3AHRCMA1 | |
| SCHEMBL12016987 | 0.70 | USP2 (0.42) | MAPTCRBNHDAC3KMT2ASMYD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101987848-A | New dihydroindolone derivatives, method of preparing same and pharmaceutical compositions containing them | SERVIER LAB | 2011-03-23 | — | — | CN | disclosed |