Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 5/20 | 0.35 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.34 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 5/20 | 0.33 |
| ▸ | JAK3 | P52333 | 4/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27805849 | 0.90 | P2RY14 (0.36) | SYKP2RY14ZAP70JAK2JAK3 | |
| SCHEMBL28790529 | 0.88 | STK17A (0.38) | IGF1RSYKZAP70JAK2JAK3 | |
| SCHEMBL28787067 | 0.88 | JAK3 (0.35) | IGF1RSYKP2RY14ZAP70JAK2 | |
| SCHEMBL27806015 | 0.88 | MAP3K12 (0.37) | IGF1RSYKZAP70JAK2JAK3 | |
| SCHEMBL28790511 | 0.87 | JAK3 (0.38) | SYKZAP70JAK2JAK3PTK2 | |
| SCHEMBL27826853 | 0.87 | ZAP70 (0.35) | IGF1RSYKZAP70JAK2JAK3 | |
| SCHEMBL27826714 | 0.87 | MAP4K1 (0.37) | SYKZAP70JAK2JAK3PTK2 | |
| SCHEMBL27806329 | 0.87 | BTK (0.36) | IGF1RJAK2JAK3PTK2ALK | |
| SCHEMBL27806236 | 0.87 | JAK2 (0.38) | SYKZAP70JAK2JAK3PTK2 | |
| SCHEMBL27826488 | 0.87 | SYK (0.35) | SYKZAP70JAK3BTKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101990539-A | Compounds and compositions as kinase inhibitors | IRM LLC | 2011-03-23 | — | — | CN | disclosed |