SCHEMBL2780705

SCHEMBL2780705

CC(C)(C)C(CCN1CCC[C@@H]1Cn1nc(Cc2ccc(Cl)cc2)c2ccccc2c1=O)NC(=O)O

nearest known ligand 0.66

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
HRH1 P35367 20/20 0.66
ADRA1A P35348 18/20 0.66
KCNH2 Q12809 17/20 0.66
ADRA1B P35368 17/20 0.66
HRH3 Q9Y5N1 4/20 0.66
CYP3A4 P08684 2/20 0.61
CYP2C9 P11712 2/20 0.61
CYP2C19 P33261 2/20 0.61
CYP2D6 P10635 2/20 0.61
HRH2 P25021 2/20 0.61
HTR2B P41595 2/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2984655 0.83 HRH1 (0.77) HRH1ADRA1AKCNH2ADRA1BHRH3
SCHEMBL3000061 0.83 HRH1 (0.71) HRH1ADRA1AKCNH2ADRA1BHRH3
SCHEMBL13241530 0.83 HRH1 (0.71) HRH1ADRA1AKCNH2ADRA1BHRH3
SCHEMBL2991067 0.83 HRH1 (0.70) HRH1ADRA1AKCNH2ADRA1BHRH3
SCHEMBL13241533 0.83 HRH1 (0.70) HRH1ADRA1AKCNH2ADRA1BHRH3
SCHEMBL3000100 0.83 HRH1 (0.75) HRH1ADRA1AKCNH2ADRA1BHRH3
SCHEMBL3000554 0.82 HRH1 (0.69) HRH1ADRA1AKCNH2ADRA1BHRH3
SCHEMBL2988413 0.82 HRH1 (0.75) HRH1ADRA1AKCNH2ADRA1BHRH3
SCHEMBL13241524 0.82 HRH1 (0.77) HRH1ADRA1AKCNH2ADRA1BHRH3
SCHEMBL2994070 0.82 HRH1 (0.80) HRH1ADRA1AKCNH2ADRA1BHRH3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2215082-A1 PHTHALAZINE AND PYRIDO Ý3,4-D¨PYRIDAZ INE COMPOUNDS AS H1 RECEPTOR ANTAGONISTS Glaxo Group Limited (GB) 2010-08-11 EP disclosed
EP-2091538-A2 4-BENZYL-L(2H)-PHTHALAZINONES AS H1 RECEPTOR ANTAGONISTS Glaxo Group Limited (GB) 2009-08-26 EP disclosed
WO-2009047336-A1 PHTHALAZINE AND PYRIDO [3,4-D] PYRIDAZ INE COMPOUNDS AS H1 RECEPTOR ANTAGONISTS GLAXO GROUP LIMITED (GB) 2009-04-16 WO disclosed
WO-2008074803-A2 4-BENZYL-L ( 2H) -PHTHALAZINONES AS H1 RECEPTOR ANTAGONISTS GLAXO GROUP LIMITED (GB) 2008-06-26 WO disclosed