Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 6/20 | 0.48 |
| ▸ | CDK2 | P24941 | 4/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.47 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.42 |
| ▸ | EGFR | P00533 | 5/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.39 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27809481 | 0.88 | GSK3B (0.49) | GSK3BCDK2DYRK1BMKNK2ACVR1 | |
| SCHEMBL28787549 | 0.83 | GSK3B (0.43) | GSK3BCDK2MKNK2ACVR1EGFR | |
| SCHEMBL2540053 | 0.83 | GSK3B (0.50) | GSK3BCDK2DYRK1BMKNK2ACVR1 | |
| SCHEMBL2543346 | 0.82 | MKNK2 (0.51) | GSK3BCDK2DYRK1BMKNK2EGFR | |
| SCHEMBL2542328 | 0.81 | CDK1 (0.59) | GSK3BCDK2 | |
| SCHEMBL2545739 | 0.78 | CCNT1 (0.57) | GSK3BCDK2IGF1R | |
| SCHEMBL2542950 | 0.77 | ACVR1 (0.61) | GSK3BCDK2DYRK1BMKNK2ACVR1 | |
| SCHEMBL2543915 | 0.77 | ACVR1 (0.53) | CDK2DYRK1BACVR1DYRK1ADYRK3 | |
| SCHEMBL2544927 | 0.77 | JAK2 (0.56) | CDK2DYRK1BACVR1EGFRDYRK1A | |
| SCHEMBL2543938 | 0.76 | ACVR1 (0.61) | CDK2DYRK1BACVR1DYRK1AIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101723936-A | Kinase suppressor and pharmaceutical application thereof | SHANGHAI GENOMICS INC | 2010-06-09 | — | — | CN | claimed |
| CN-101723936-A | Kinase suppressor and pharmaceutical application thereof | SHANGHAI GENOMICS INC | 2010-06-09 | — | — | CN | disclosed |