Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 9/20 | 0.44 |
| ▸ | CTSC | P53634 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 3/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.38 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.38 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | ITK | Q08881 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27844365 | 0.90 | CDK4 (0.46) | AURKAMAPK8CSNK2A1HDAC1HDAC6 | |
| SCHEMBL27844446 | 0.77 | AURKA (0.42) | AURKAMAPK8CSNK2A1CSNK2A2CSNK2B | |
| SCHEMBL3714982 | 0.68 | AURKA (0.53) | AURKACTSCCSNK2A1HDAC3HDAC1 | |
| SCHEMBL6808912 | 0.67 | CDK4 (0.72) | AURKAPTK2CDK4 | |
| SCHEMBL6807088 | 0.66 | CDK4 (0.75) | CDK4 | |
| SCHEMBL6813169 | 0.65 | CDK4 (0.59) | AURKACTSCCDK4 | |
| SCHEMBL3714986 | 0.65 | KDM4E (0.48) | AURKACTSCCSNK2A1SYKPTK2 | |
| SCHEMBL6806873 | 0.65 | CDK4 (0.61) | AURKACTSCCDK4 | |
| SCHEMBL27825347 | 0.64 | CDK4 (0.46) | AURKAMAPK8CSNK2A1HDAC1HDAC6 | |
| SCHEMBL6808567 | 0.62 | CDK4 (0.71) | CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102341400-A | Pyrrolopyrimidines useful as kinase inhibitors | MEDICAL RES COUNCIL TECHNOLOGY | 2012-02-01 | — | — | CN | claimed |
| CN-102341400-A | Pyrrolopyrimidines useful as kinase inhibitors | MEDICAL RES COUNCIL TECHNOLOGY | 2012-02-01 | — | — | CN | disclosed |