Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 16/20 | 0.67 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.59 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.59 |
| ▸ | CDK2 | P24941 | 4/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.48 |
| ▸ | CDK9 | P50750 | 3/20 | 0.48 |
| ▸ | AXL | P30530 | 2/20 | 0.47 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.47 |
| ▸ | PAK4 | O96013 | 1/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1456700 | 0.86 | PDPK1 (0.66) | PDPK1PIK3CAPIK3CGPRKD3PRKD2 | |
| SCHEMBL1603767 | 0.81 | PDPK1 (1.00) | PDPK1PIK3CAPIK3CGCDK2CCNT1 | |
| SCHEMBL1603268 | 0.80 | PDPK1 (0.74) | PDPK1PIK3CAPIK3CG | |
| SCHEMBL1603418 | 0.78 | PDPK1 (1.00) | PDPK1PIK3CAPIK3CGCDK2CCNT1 | |
| SCHEMBL1604511 | 0.78 | PDPK1 (0.72) | PDPK1PIK3CAPIK3CGCDK2CCNT1 | |
| SCHEMBL1604908 | 0.78 | PDPK1 (0.75) | PDPK1PIK3CAPIK3CGCDK2CCNT1 | |
| SCHEMBL1603822 | 0.77 | PDPK1 (0.70) | PDPK1PIK3CAPIK3CGCDK2CCNT1 | |
| SCHEMBL1604708 | 0.77 | PDPK1 (1.00) | PDPK1PIK3CAPIK3CGCDK2CCNT1 | |
| SCHEMBL1456058 | 0.76 | PDPK1 (0.79) | PDPK1PIK3CAPIK3CGCDK2CCNT1 | |
| SCHEMBL1604923 | 0.76 | PDPK1 (1.00) | PDPK1PIK3CAPIK3CGCDK2CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102056926-B | Pyrrolopyridinylpyrimidin-2-ylamine derivatives | MERCK PATENT GMBH | 2013-10-16 | — | — | CN | claimed |
| CN-102056926-A | Pyrrolopyridinylpyrimidin-2-ylamine derivatives | MERCK PATENT GMBH | 2011-05-11 | — | — | CN | claimed |
| CN-102056926-B | Pyrrolopyridinylpyrimidin-2-ylamine derivatives | MERCK PATENT GMBH | 2013-10-16 | — | — | CN | disclosed |
| CN-102056926-A | Pyrrolopyridinylpyrimidin-2-ylamine derivatives | MERCK PATENT GMBH | 2011-05-11 | — | — | CN | disclosed |