Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
| ▸ | GALR3 | O60755 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20969166 | 0.76 | TSHR (0.33) | TSHR | |
| SCHEMBL18107140 | 0.76 | TSHR (0.33) | TSHR | |
| SCHEMBL18107138 | 0.76 | TSHR (0.33) | TSHR | |
| SCHEMBL17106421 | 0.76 | TSHR (0.33) | TSHR | |
| SCHEMBL17130772 | 0.76 | TSHR (0.33) | TSHR | |
| SCHEMBL17106417 | 0.76 | TSHR (0.33) | TSHR | |
| SCHEMBL17106419 | 0.76 | TSHR (0.33) | TSHR | |
| SCHEMBL20969167 | 0.76 | TSHR (0.33) | TSHR | |
| SCHEMBL2484323 | 0.74 | TSHR (0.44) | TSHRCHRM2CHRM4CHRM1TBXA2R | |
| SCHEMBL12694792 | 0.74 | TSHR (0.44) | TSHRCHRM2CHRM4CHRM1TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102089287-B | Tetrahydrocinnolines as 11 beta HSD1 inhibitors for diabetes | HOFFMANN LA ROCHE | 2013-10-23 | — | — | CN | disclosed |
| CN-102089287-A | Tetrahydrocinnolines as 11 beta HSD1 inhibitors for diabetes | HOFFMANN LA ROCHE | 2011-06-08 | — | — | CN | disclosed |