Toluene

Toluene

SCHEMBL27848754

Cc1ccccc1.O=C=Nc1ccccc1N=C=O

nearest known ligand 0.61

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 4/20 0.61
TSHR P16473 2/20 0.50
ACHE P22303 2/20 0.50
LMNA P02545 1/20 0.50
ALOX12 P18054 1/20 0.50
TRPA1 O75762 1/20 0.44
GABRA1 P14867 1/20 0.38
GABRB2 P47870 1/20 0.38
HPGD P15428 4/20 0.37
ALDH1A1 P00352 4/20 0.37
TDP1 Q9NUW8 1/20 0.37
CES2 O00748 1/20 0.35
CES1 P23141 1/20 0.35
KDM4E B2RXH2 3/20 0.33
POLB P06746 2/20 0.33
MAPT P10636 1/20 0.33
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
VCP P55072 1/20 0.32
NPC1 O15118 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Toluene SCHEMBL28871050 0.90 CYP3A4 (0.80) CYP3A4TSHRACHELMNAALOX12
Benzene SCHEMBL28766229 0.88 CYP3A4 (0.61) CYP3A4TSHRLMNATRPA1GABRA1
Toluene SCHEMBL17981107 0.87 CYP3A4 (0.63) CYP3A4TSHRACHELMNAALOX12
Hexamethylbenzene SCHEMBL28101399 0.86 CYP3A4 (0.74) CYP3A4TSHRACHETRPA1GABRA1
SCHEMBL15431 0.85 CYP3A4 (0.64) CYP3A4TSHRLMNATRPA1GABRA1
SCHEMBL29395383 0.85 CYP3A4 (0.64) CYP3A4TSHRLMNATRPA1GABRA1
Toluene SCHEMBL28941697 0.85 CYP3A4 (0.71) CYP3A4TSHRACHELMNAALOX12
Toluene SCHEMBL28374872 0.83 CYP3A4 (0.48) CYP3A4TSHRACHELMNAALOX12
Toluene SCHEMBL27882185 0.83 CYP3A4 (0.53) CYP3A4TSHRACHELMNAALOX12
Water SCHEMBL28526910 0.83 CYP3A4 (0.61) CYP3A4TSHRLMNATRPA1GABRA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102343698-B Hard film and preparation method thereof BYD CO LTD 2015-01-14 CN disclosed
CN-102343698-A Hard film and preparation method thereof BYD CO LTD 2012-02-08 CN disclosed