Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 18/20 | 0.54 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1304580 | 0.90 | PDE10A (0.65) | PDE10ATRPV1 | |
| SCHEMBL11989068 | 0.83 | PDE10A (0.59) | PDE10A | |
| SCHEMBL1303346 | 0.80 | PDE10A (0.53) | PDE10A | |
| SCHEMBL7939118 | 0.79 | PDE10A (0.46) | PDE10A | |
| SCHEMBL11989136 | 0.79 | PDE10A (0.46) | PDE10A | |
| SCHEMBL1303691 | 0.79 | PDE10A (0.46) | PDE10A | |
| SCHEMBL13474538 | 0.77 | PDE10A (0.82) | PDE10A | |
| SCHEMBL14799404 | 0.77 | PDE10A (0.86) | PDE10A | |
| SCHEMBL1304144 | 0.77 | PDE10A (0.61) | PDE10A | |
| SCHEMBL2641675 | 0.75 | PDE10A (0.61) | PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102300860-A | Pyrazine compounds as phosphodiesterase 10 inhibitors | — | 2011-12-28 | — | — | CN | claimed |
| CN-102300860-A | Pyrazine compounds as phosphodiesterase 10 inhibitors | — | 2011-12-28 | — | — | CN | disclosed |