SCHEMBL2785147

SCHEMBL2785147

Cc1sc(N2CCN(C)CC2)nc1CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(=O)O)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
PPARG P37231 20/20 1.00
PPARA Q07869 10/20 1.00
PPARD Q03181 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2785140 1.00 PPARG (1.00) PPARGPPARAPPARD
Hydrochloric Acid SCHEMBL7705753 0.99 PPARG (0.98) PPARGPPARAPPARD
Hydrochloric Acid SCHEMBL7705758 0.99 PPARG (0.98) PPARGPPARAPPARD
SCHEMBL2786940 0.92 PPARG (1.00) PPARGPPARAPPARD
SCHEMBL7926400 0.92 PPARG (1.00) PPARGPPARAPPARD
SCHEMBL2789319 0.92 PPARG (1.00) PPARGPPARAPPARD
SCHEMBL2789322 0.92 PPARG (1.00) PPARGPPARAPPARD
SCHEMBL2786712 0.91 PPARG (1.00) PPARGPPARAPPARD
SCHEMBL2786718 0.91 PPARG (1.00) PPARGPPARAPPARD
SCHEMBL2786546 0.90 PPARG (1.00) PPARGPPARAPPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20020137794-A1 Retinoic acid receptor (RAR) agonists, agonists for steroid/thyroid hormone receptor superfamily, and an agonist for a heterodimer partner SALK INSTITUTE FOR BIOLOGICAL STUDIES, THE 2002-09-26 US claimed
US-6436993-B1 SYNERGISTIC MIXTURES OF RETINOIC ACID RECEPTOR (RAR) ANTAGONISTS AND STEROID, THYROID OR RETINOID RECEPTOR AGONISTS SUCH AS PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS USED TO CONTROL CELLULAR PROCESSES THE SALK INSTITUTE FOR BIOLOGICAL STUDIES 2002-08-20 US claimed
US-20110300129-A1 SYSTEMS AND METHODS FOR ENHANCING VACCINE EFFICACY UNIVERSITY OF ROCHESTER (US) 2011-12-08 US disclosed
WO-2010075037-A1 SYSTEMS AND METHODS FOR ENHANCING VACCINE EFFICACY UNIVERSITY OF ROCHESTER (US) 2010-07-01 WO disclosed
EP-2081599-A2 COMPOUNDS, KITS AND METHODS FOR CONFERRING CYTOPROTECTION University of Debrecen (HU) 2009-07-29 EP disclosed
US-20090155228-A1 COMPOUNDS, KITS AND METHODS FOR CONFERRING CYTOPROTECTION UNIVERSITY OF DEBRECEN (HU) 2009-06-18 US disclosed
WO-2007144679-A2 COMPOUNDS, KITS AND METHODS FOR CONFERRING CYTOPROTECTION UNIVERSITY OF DEBRECEN (HU) 2007-12-21 WO disclosed
US-20020137794-A1 Retinoic acid receptor (RAR) agonists, agonists for steroid/thyroid hormone receptor superfamily, and an agonist for a heterodimer partner SALK INSTITUTE FOR BIOLOGICAL STUDIES, THE 2002-09-26 US disclosed
US-6436993-B1 SYNERGISTIC MIXTURES OF RETINOIC ACID RECEPTOR (RAR) ANTAGONISTS AND STEROID, THYROID OR RETINOID RECEPTOR AGONISTS SUCH AS PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS USED TO CONTROL CELLULAR PROCESSES THE SALK INSTITUTE FOR BIOLOGICAL STUDIES 2002-08-20 US disclosed
US-6294580-B1 FOR THERAPY AND PROPHYLAXIS OF TYPE II OR NON-INSULIN DEPENDENT DIABETES MELLITUS, HYPERGLYCAEMIA, DYSLIPIDEMIA, TYPE II DIABETES, TYPE I DIABETES, HYPERTRIGLYCERIDEMIA, SYNDROME X, INSULIN RESISTANCE, HEART FAILURE GLAXO WELLCOME INC. 2001-09-25 US disclosed
US-6291496-B1 E.G., WITH OVEREXPRESSSION OF HER-2/NEU OR OVEREXPRESSION OF EPIDERMAL GROWTH FACTOR RECEPTOR, ARE TREATED WITH STRONGLY BINDING PPAR GAMMA LIGANDS. CORNELL RESEARCH FOUNDATION, INC. 2001-09-18 US disclosed
EP-0888317-B1 SUBSTITUTED 4-HYDROXY-PHENYLALCANOIC ACID DERIVATIVES WITH AGONIST ACTIVITY TO PPAR-GAMMA GLAXO GROUP LTD (GB) 2001-09-12 EP disclosed
WO-2001047555-A1 TREATING CANCERS ASSOCIATED WITH OVEREXPRESSION OF CLASS I FAMILY OF RECEPTOR TYROSINE KINASES CORNELL RESEARCH FOUNDATION, INC. (US) 2001-07-05 WO disclosed
EP-0888317-A1 SUBSTITUTED 4-HYDROXY-PHENYLALCANOIC ACID DERIVATIVES WITH AGONIST ACTIVITY TO PPAR-GAMMA GLAXO GROUP LIMITED (GB) 1999-01-07 EP disclosed
WO-1997031907-A1 SUBSTITUTED 4-HYDROXY-PHENYLALCANOIC ACID DERIVATIVES WITH AGONIST ACTIVITY TO PPAR-GAMMA GLAXO GROUP LIMITED (GB) 1997-09-04 WO disclosed