Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | JAK2 | O60674 | 4/20 | 0.47 |
| ▸ | JAK1 | P23458 | 2/20 | 0.47 |
| ▸ | JAK3 | P52333 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.43 |
| ▸ | FEN1 | P39748 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | TTK | P33981 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL141118 | 0.93 | TYK2 (0.55) | TYK2HPGDTSHRL3MBTL1JAK2 | |
| SCHEMBL144961 | 0.88 | TYK2 (0.49) | TYK2HPGDJAK2JAK1JAK3 | |
| SCHEMBL149035 | 0.87 | TYK2 (0.53) | TYK2HPGDJAK2JAK1JAK3 | |
| SCHEMBL142118 | 0.82 | TTK (0.51) | TYK2HPGDJAK2ALDH1A1MAPT | |
| SCHEMBL27833935 | 0.81 | TYK2 (0.55) | TYK2HPGDTSHRJAK3LMNA | |
| SCHEMBL142450 | 0.80 | TYK2 (0.50) | TYK2HPGDTSHRLMNAALDH1A1 | |
| SCHEMBL13952297 | 0.79 | HPGD (0.60) | HPGDTSHRL3MBTL1ALDH1A1EPHX2 | |
| SCHEMBL141845 | 0.79 | TYK2 (0.48) | TYK2HPGDTSHRJAK2JAK1 | |
| SCHEMBL13284559 | 0.78 | TYK2 (0.51) | TYK2HPGDTSHRL3MBTL1JAK2 | |
| SCHEMBL140875 | 0.78 | EPHX2 (0.57) | TYK2HPGDJAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102325752-B | Carbazole and carboline kinase inhibitors | BRISTOL MYERS SQUIBB CO | 2015-02-04 | — | — | CN | disclosed |
| CN-102325752-A | Carbazole and carboline kinase inhibitors | BRISTOL MYERS SQUIBB CO | 2012-01-18 | — | — | CN | disclosed |