Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.45 |
| ▸ | KDM1A | O60341 | 2/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.43 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.41 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | USP5 | P45974 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2860924 | 0.99 | HTR2C (0.46) | HTR2CKDM1AFFAR1DGAT1SOAT1 | |
| SCHEMBL27869978 | 0.88 | FFAR1 (0.37) | FFAR1FFAR4S1PR4S1PR1S1PR3 | |
| SCHEMBL13604396 | 0.86 | GUSB (0.43) | HTR2CKDM1ALMNAMAPTSMN1; SMN2 | |
| SCHEMBL2493402 | 0.85 | PSEN1 (0.45) | HTR2CKDM1ADGAT1SOAT1FFAR4 | |
| SCHEMBL21820688 | 0.85 | PSEN1 (0.45) | HTR2CKDM1ADGAT1SOAT1FFAR4 | |
| SCHEMBL4493249 | 0.85 | PSEN1 (0.45) | HTR2CKDM1ADGAT1SOAT1FFAR4 | |
| SCHEMBL2861143 | 0.85 | PSEN1 (0.45) | HTR2CKDM1ADGAT1SOAT1FFAR4 | |
| Hydrochloric Acid SCHEMBL2874986 | 0.84 | PSEN1 (0.44) | HTR2CKDM1ADGAT1SOAT1FFAR4 | |
| Hydrochloric Acid SCHEMBL2161847 | 0.84 | PSEN1 (0.44) | HTR2CKDM1ADGAT1SOAT1FFAR4 | |
| SCHEMBL2852835 | 0.82 | FFAR4 (0.47) | KDM1ADGAT1SOAT1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102459246-B | Isoxazol-3 (2H) -one analogs as therapeutic agents | ASTRAZENECA AB | 2014-05-07 | — | — | CN | disclosed |
| CN-102459246-A | Isoxazol-3 (2H) -one analogs as therapeutic agents | ASTRAZENECA AB | 2012-05-16 | — | — | CN | disclosed |