SCHEMBL2785308

SCHEMBL2785308

COC(=O)[C@H](Cc1ccc(OCCN2c3ccccc3Oc3ccccc32)cc1)Nc1ccccc1C(=O)c1ccccc1

nearest known ligand 0.58

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PPARG P37231 20/20 0.58
PPARA Q07869 3/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6636438 1.00 PPARG (0.58) PPARGPPARA
SCHEMBL2786676 0.92 PPARG (0.66) PPARGPPARA
SCHEMBL6636646 0.92 PPARG (0.66) PPARGPPARA
SCHEMBL6679623 0.89 PPARG (0.61) PPARGPPARA
SCHEMBL6635105 0.89 PPARG (0.61) PPARGPPARA
SCHEMBL6637185 0.88 PPARG (0.58) PPARGPPARA
SCHEMBL7914564 0.83 PPARG (0.70) PPARGPPARA
SCHEMBL2788918 0.82 PPARG (0.62) PPARGPPARA
SCHEMBL6638351 0.82 PPARG (0.62) PPARGPPARA
SCHEMBL2786254 0.82 PPARG (0.55) PPARGPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1414806-A1 NOVEL VINYL N-(2-BENZOYLPHENYL)-L-TYROSINE DERIVATIVES AND THEIR USE AS ANTIDIABETICS ETC NOVO NORDISK A/S (DK) 2004-05-06 EP claimed
US-20030055076-A1 Novel compounds, their preparation and use NOVO NORDISK A/S (DK) 2003-03-20 US claimed
WO-2003011834-A1 NOVEL VINYL N-(2-BENZOYLPHENYL)-L-TYROSINE DERIVATIVES AND THEIR USE AS ANTIDIABETICS ETC NOVO NORDISK A/S (DK) 2003-02-13 WO claimed
US-20110300129-A1 SYSTEMS AND METHODS FOR ENHANCING VACCINE EFFICACY UNIVERSITY OF ROCHESTER (US) 2011-12-08 US disclosed
WO-2010075037-A1 SYSTEMS AND METHODS FOR ENHANCING VACCINE EFFICACY UNIVERSITY OF ROCHESTER (US) 2010-07-01 WO disclosed
EP-1414806-A1 NOVEL VINYL N-(2-BENZOYLPHENYL)-L-TYROSINE DERIVATIVES AND THEIR USE AS ANTIDIABETICS ETC NOVO NORDISK A/S (DK) 2004-05-06 EP disclosed
US-20030055076-A1 Novel compounds, their preparation and use NOVO NORDISK A/S (DK) 2003-03-20 US disclosed
WO-2003011834-A1 NOVEL VINYL N-(2-BENZOYLPHENYL)-L-TYROSINE DERIVATIVES AND THEIR USE AS ANTIDIABETICS ETC NOVO NORDISK A/S (DK) 2003-02-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030055076-A1 Novel compounds, their preparation and use PPARG, PPARA, PPARD PPARG 1/4885PPARA 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.