Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.48 |
| ▸ | TP53 | P04637 | 7/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.39 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2788818 | 0.85 | TP53 (0.51) | SMN1; SMN2TP53MAPTEPHX2ALOX15 | |
| SCHEMBL2784919 | 0.85 | SMN1; SMN2 (0.56) | SMN1; SMN2TP53MAPTEPHX2RAB9A | |
| SCHEMBL2786357 | 0.82 | SMN1; SMN2 (0.41) | SMN1; SMN2TP53MAPTKMT2ANPC1 | |
| SCHEMBL2784837 | 0.82 | EPHX2 (0.52) | SMN1; SMN2TP53MAPTEPHX2KMT2A | |
| SCHEMBL2785316 | 0.82 | TP53 (0.52) | SMN1; SMN2TP53MAPTEPHX2ALOX15 | |
| SCHEMBL2788190 | 0.81 | SMN1; SMN2 (0.55) | SMN1; SMN2TP53MAPTMAPK1EPHX2 | |
| SCHEMBL2785705 | 0.81 | TP53 (0.44) | SMN1; SMN2TP53MAPTEPHX2KMT2A | |
| SCHEMBL2785867 | 0.79 | SMN1; SMN2 (0.47) | SMN1; SMN2TP53MAPTMAPK1EPHX2 | |
| SCHEMBL2784404 | 0.79 | TP53 (0.55) | SMN1; SMN2TP53MAPTMAPK1EPHX2 | |
| SCHEMBL2785768 | 0.78 | SMN1; SMN2 (0.51) | SMN1; SMN2TP53MAPTMAPK1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881967-B1 | SUBSTITUTED BENZO(D)ISOXAZOL-3-YL AMINE COMPOUNDS AS ANALGESICS | GRUENENTHAL GMBH (DE) | 2010-04-28 | — | — | EP | claimed |