Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetaldehyde SCHEMBL27920822 | 0.86 | MEN1 (0.49) | MEN1KMT2ARAB9AGRIN2BCHRM2 | |
| Propionaldehyde SCHEMBL27792856 | 0.86 | CHRM2 (0.44) | KMT2ACHRM2CHRM1CHRM3POLB | |
| SCHEMBL27278405 | 0.84 | MEN1 (0.50) | MEN1KMT2ARAB9AGRIN2BACHE | |
| SCHEMBL27690846 | 0.84 | MEN1 (0.50) | MEN1KMT2ARAB9AGRIN2BACHE | |
| Alcohol SCHEMBL28020926 | 0.82 | MEN1 (0.49) | MEN1KMT2ARAB9AGRIN2BACHE | |
| Chloromethane SCHEMBL27654417 | 0.81 | MEN1 (0.50) | MEN1KMT2ARAB9AGRIN2BACHE | |
| Ethane SCHEMBL27840710 | 0.81 | MEN1 (0.50) | MEN1KMT2ARAB9AGRIN2BACHE | |
| SCHEMBL29635658 | 0.81 | — | — | |
| SCHEMBL165706 | 0.81 | — | — | |
| SCHEMBL6201152 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102532106-A | Synthesis method of crizotinib serving as antitumor molecular targeting medicament | JINAN NIUHUA MEDICAL TECHNOLOGY CO LTD | 2012-07-04 | — | — | CN | claimed |
| CN-102532106-A | Synthesis method of crizotinib serving as antitumor molecular targeting medicament | JINAN NIUHUA MEDICAL TECHNOLOGY CO LTD | 2012-07-04 | — | — | CN | disclosed |