Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 12/20 | 0.82 |
| ▸ | NTRK2 | Q16620 | 8/20 | 0.66 |
| ▸ | NTRK3 | Q16288 | 4/20 | 0.58 |
| ▸ | RAF1 | P04049 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.48 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL398755 | 0.92 | NTRK1 (0.81) | NTRK1NTRK2NTRK3RAF1AURKA | |
| SCHEMBL398756 | 0.92 | NTRK1 (0.81) | NTRK1NTRK2NTRK3RAF1AURKA | |
| SCHEMBL396214 | 0.82 | NTRK1 (0.85) | NTRK1NTRK2NTRK3RAF1AURKA | |
| SCHEMBL396213 | 0.82 | NTRK1 (0.85) | NTRK1NTRK2NTRK3RAF1AURKA | |
| SCHEMBL14073763 | 0.80 | NTRK2 (0.73) | NTRK1NTRK2NTRK3RAF1AURKA | |
| SCHEMBL395043 | 0.79 | NTRK2 (0.89) | NTRK1NTRK2NTRK3RAF1AURKA | |
| SCHEMBL395044 | 0.79 | NTRK2 (0.89) | NTRK1NTRK2NTRK3RAF1AURKA | |
| SCHEMBL398255 | 0.78 | NTRK2 (1.00) | NTRK1NTRK2NTRK3RAF1AURKA | |
| SCHEMBL398254 | 0.78 | NTRK2 (1.00) | NTRK1NTRK2NTRK3RAF1AURKA | |
| SCHEMBL397888 | 0.77 | NTRK1 (1.00) | NTRK1NTRK2NTRK3RAF1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101056632-B | Compounds and compositions as protein kinase inhibitors | IRM LLC (BM) | 2011-12-07 | — | — | CN | disclosed |