Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 2/20 | 0.41 |
| ▸ | BCR | P11274 | 2/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | ITK | Q08881 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | GALR2 | O43603 | 1/20 | 0.37 |
| ▸ | GALR1 | P47211 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isophthalic Acid SCHEMBL27864979 | 0.88 | AURKA (0.51) | MAPK1CYP2C9AURKANPC1RAB9A | |
| SCHEMBL1506469 | 0.86 | MAPK1 (0.46) | MAPK1NPY5RCYP2D6CYP2C9KCNH2 | |
| SCHEMBL10010866 | 0.85 | MAPK1 (0.46) | MAPK1NPY5RCYP2D6CYP2C9KCNH2 | |
| SCHEMBL1506231 | 0.84 | MAPK1 (0.45) | MAPK1NPY5RCYP2D6CYP2C9KCNH2 | |
| SCHEMBL10009161 | 0.84 | MAPK1 (0.50) | MAPK1NPY5RCYP2D6CYP2C9KCNH2 | |
| SCHEMBL1506242 | 0.83 | MAPK1 (0.46) | MAPK1NPY5RCYP2D6CYP2C9KCNH2 | |
| SCHEMBL10010154 | 0.82 | MAPK1 (0.44) | MAPK1NPY5RCYP2D6CYP2C9KCNH2 | |
| SCHEMBL10008365 | 0.81 | MAPK1 (0.43) | MAPK1NPY5RCYP2D6CYP2C9KCNH2 | |
| SCHEMBL1506340 | 0.80 | CYP2D6 (0.46) | MAPK1NPY5RCYP2D6CYP2C9KCNH2 | |
| SCHEMBL10009879 | 0.80 | MAPK1 (0.45) | MAPK1ABL1BCRNPY5RCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102574832-B | Substituted N-phenyl-1-(4-pyridinyl)-1H-pyrazol-3-amines | JANSSEN PHARMACEUTICA NV | 2014-09-24 | — | — | CN | disclosed |
| CN-102574832-A | Substituted N-phenyl-1-(4-pyridinyl)-1H-pyrazol-3-amines | JANSSEN PHARMACEUTICA NV | 2012-07-11 | — | — | CN | disclosed |