Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 12/20 | 0.42 |
| ▸ | DPP4 | P27487 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | S100B | P04271 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.38 |
| ▸ | LGMN | Q99538 | 2/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2053813 | 0.82 | GAA (0.51) | NOTUMGAAMAPTMAPK1HTT | |
| SCHEMBL962246 | 0.82 | HTT (0.56) | NOTUMGAAMAPTMAPK1HTT | |
| SCHEMBL2967963 | 0.82 | NOTUM (0.48) | NOTUMDPP4GAAMAPTMAPK1 | |
| SCHEMBL2977643 | 0.82 | NOTUM (0.48) | NOTUMDPP4GAAMAPTMAPK1 | |
| SCHEMBL2967961 | 0.82 | NOTUM (0.48) | NOTUMDPP4GAAMAPTMAPK1 | |
| SCHEMBL2980263 | 0.81 | NOTUM (0.42) | NOTUMDPP4SIRT6LGMN | |
| SCHEMBL27884820 | 0.81 | NOTUM (0.40) | NOTUMDPP4GAAMAPTMAPK1 | |
| SCHEMBL2012912 | 0.81 | HTT (0.59) | NOTUMGAAMAPTMAPK1HTT | |
| SCHEMBL2050735 | 0.79 | NOTUM (0.49) | NOTUMDPP4 | |
| SCHEMBL2832366 | 0.79 | PDK2 (0.48) | NOTUMDPP4HTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102652128-A | 4-Oxo-1H-quinoline-3-carboxamides as modulators of ATP-binding cassette transporters | VERTEX PHARMA | 2012-08-29 | — | — | CN | disclosed |