Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG | P00747 | 13/20 | 0.44 |
| ▸ | TACR1 | P25103 | 5/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL586860 | 1.00 | PLG (0.44) | PLGTACR1GABRA1GABRG2GABRB3 | |
| SCHEMBL27869832 | 1.00 | PLG (0.44) | PLGTACR1GABRA1GABRG2GABRB3 | |
| SCHEMBL581927 | 0.91 | PLG (0.44) | PLGTACR1GABRA1GABRG2GABRB3 | |
| SCHEMBL581123 | 0.90 | PLG (0.45) | PLGTACR1 | |
| SCHEMBL587277 | 0.90 | PLG (0.41) | PLGTACR1NPC1RAB9A | |
| SCHEMBL581973 | 0.90 | PLG (0.41) | PLGTACR1NPC1RAB9A | |
| SCHEMBL581234 | 0.90 | PLG (0.41) | PLGTACR1NPC1RAB9A | |
| SCHEMBL580880 | 0.90 | PLG (0.41) | PLGTACR1NPC1RAB9A | |
| SCHEMBL581599 | 0.88 | PLG (0.57) | PLGTACR1GABRA1GABRG2GABRB3 | |
| SCHEMBL583170 | 0.87 | PLG (0.47) | PLGTACR1GABRA1GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102459246-B | Isoxazol-3 (2H) -one analogs as therapeutic agents | ASTRAZENECA AB | 2014-05-07 | — | — | CN | disclosed |
| CN-102459246-A | Isoxazol-3 (2H) -one analogs as therapeutic agents | ASTRAZENECA AB | 2012-05-16 | — | — | CN | disclosed |