Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | APLNR | P35414 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4643135 | 1.00 | MEN1 (0.43) | MEN1KMT2AMAPK1BTKNFKB1 | |
| SCHEMBL16409149 | 0.86 | MEN1 (0.43) | MEN1KMT2AMAPK1BTKNFKB1 | |
| SCHEMBL12557612 | 0.85 | BTK (0.38) | MEN1KMT2AMAPK1BTKNFKB1 | |
| SCHEMBL15424518 | 0.84 | MAPK1 (0.42) | MEN1KMT2AMAPK1BTKNFKB1 | |
| SCHEMBL20629740 | 0.84 | MAPK1 (0.42) | MEN1KMT2AMAPK1BTKNFKB1 | |
| SCHEMBL15424510 | 0.84 | MAPK1 (0.42) | MEN1KMT2AMAPK1BTKNFKB1 | |
| SCHEMBL2630592 | 0.84 | KMT2A (0.42) | MEN1KMT2AMAPK1BTKNFKB1 | |
| SCHEMBL18799610 | 0.83 | MEN1 (0.41) | MEN1KMT2AMAPK1BTKNFKB1 | |
| SCHEMBL28564855 | 0.81 | KMT2A (0.40) | MEN1KMT2AMAPK1BTKNFKB1 | |
| SCHEMBL9666907 | 0.80 | KMT2A (0.39) | MEN1KMT2AMAPK1BTKGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102481307-A | Treatment of klebsiella pneumoniae infections with antibacterial aminoglycoside compounds | ACHAOGEN INC | 2012-05-30 | — | — | CN | disclosed |
| CN-102481306-A | Treatment of urinary tract infections with antibacterial aminoglycoside compounds | ACHAOGEN INC | 2012-05-30 | — | — | CN | disclosed |