Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 17/20 | 0.70 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3425036 | 1.00 | NTRK1 (0.70) | NTRK1JAK2JAK3IGF1R | |
| SCHEMBL2567488 | 0.94 | NTRK1 (0.77) | NTRK1JAK2JAK3IGF1R | |
| SCHEMBL4694176 | 0.94 | NTRK1 (0.77) | NTRK1JAK2JAK3IGF1R | |
| SCHEMBL2573786 | 0.90 | NTRK1 (0.61) | NTRK1JAK2JAK3IGF1R | |
| SCHEMBL2573790 | 0.90 | NTRK1 (0.61) | NTRK1JAK2JAK3IGF1R | |
| SCHEMBL4299264 | 0.88 | NTRK1 (0.68) | NTRK1IGF1R | |
| SCHEMBL3126553 | 0.88 | NTRK1 (0.68) | NTRK1IGF1R | |
| SCHEMBL2564629 | 0.88 | NTRK1 (0.68) | NTRK1JAK2JAK3IGF1R | |
| SCHEMBL27856018 | 0.88 | NTRK1 (0.68) | NTRK1JAK2JAK3IGF1R | |
| SCHEMBL3130155 | 0.86 | NTRK1 (0.88) | NTRK1JAK2JAK3IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101155800-B | Pyrazolylaminopyridine derivatives useful as kinase inhibitors | ASTRAZENECA AB | 2012-05-23 | — | — | CN | disclosed |