Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 6/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 7/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.43 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2783815 | 0.93 | TP53 (0.52) | TP53SMN1; SMN2MAPTHIF1AALOX15 | |
| SCHEMBL2788417 | 0.86 | SMN1; SMN2 (0.49) | TP53SMN1; SMN2MAPTHIF1AALOX15 | |
| SCHEMBL2785768 | 0.84 | SMN1; SMN2 (0.51) | TP53SMN1; SMN2MAPTHIF1AALOX15 | |
| SCHEMBL2784672 | 0.83 | TP53 (0.48) | TP53SMN1; SMN2MAPTHIF1AALOX15 | |
| SCHEMBL2787234 | 0.80 | SMN1; SMN2 (0.47) | TP53SMN1; SMN2MAPTHIF1AALOX15 | |
| SCHEMBL2788190 | 0.79 | SMN1; SMN2 (0.55) | TP53SMN1; SMN2MAPTHIF1AALOX15 | |
| SCHEMBL2786507 | 0.79 | TP53 (0.49) | TP53SMN1; SMN2MAPTHIF1AALOX15 | |
| SCHEMBL2786232 | 0.78 | SMN1; SMN2 (0.47) | TP53SMN1; SMN2MAPTHIF1AALOX15 | |
| SCHEMBL2786481 | 0.76 | SMN1; SMN2 (0.51) | TP53SMN1; SMN2MAPTHIF1AALOX15 | |
| SCHEMBL2786687 | 0.75 | SMN1; SMN2 (0.49) | TP53SMN1; SMN2MAPTHIF1AALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881967-B1 | SUBSTITUTED BENZO(D)ISOXAZOL-3-YL AMINE COMPOUNDS AS ANALGESICS | GRUENENTHAL GMBH (DE) | 2010-04-28 | — | — | EP | claimed |