Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 12/20 | 0.51 |
| ▸ | TP53 | P04637 | 8/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | CTSV | O60911 | 2/20 | 0.35 |
| ▸ | CTSL | P07711 | 2/20 | 0.35 |
| ▸ | CTSS | P25774 | 2/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1319816 | 0.87 | MDM2 (0.50) | MDM2TP53KDM4E | |
| SCHEMBL27875551 | 0.85 | MDM2 (0.51) | MDM2TP53KDM4EMAPTTHRB | |
| SCHEMBL1322958 | 0.84 | MDM2 (0.51) | MDM2TP53KMT2A | |
| SCHEMBL1322760 | 0.83 | MDM2 (0.56) | MDM2TP53KDM4EKMT2A | |
| SCHEMBL1321538 | 0.83 | MDM2 (0.51) | MDM2TP53MAPTATM | |
| SCHEMBL3243048 | 0.83 | MDM2 (0.51) | MDM2TP53MAPTTHRBATM | |
| SCHEMBL1325985 | 0.82 | MDM2 (0.55) | MDM2TP53KDM4EKMT2A | |
| SCHEMBL1319803 | 0.82 | MDM2 (0.49) | MDM2TP53KDM4EMAPTKMT2A | |
| SCHEMBL1321776 | 0.81 | MDM2 (0.61) | MDM2TP53KDM4EKMT2A | |
| SCHEMBL1320670 | 0.80 | MDM2 (0.55) | MDM2TP53KDM4EKMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101516366-B | Oxindole derivatives as anticancer agents | HOFFMANN LA ROCHE | 2012-05-30 | — | — | CN | claimed |
| CN-101516366-B | Oxindole derivatives as anticancer agents | HOFFMANN LA ROCHE | 2012-05-30 | — | — | CN | disclosed |