Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 7/20 | 0.82 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CTSA | P10619 | 2/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28796349 | 0.91 | MDM2 (0.83) | MDM2NOTUMRIPK1CTSA | |
| SCHEMBL1443240 | 0.91 | MDM2 (1.00) | MDM2NOTUMPIN1RIPK1GABRA2 | |
| SCHEMBL27879120 | 0.89 | MDM2 (0.72) | MDM2PIN1BRD4GABRA2GABRB2 | |
| SCHEMBL27879077 | 0.87 | MDM2 (0.88) | MDM2NOTUMPIN1RIPK1GABRA2 | |
| SCHEMBL1438150 | 0.87 | MDM2 (0.88) | MDM2NOTUMPIN1RIPK1PKM | |
| SCHEMBL27862799 | 0.87 | MDM2 (0.85) | MDM2PIN1BRD4GABRA2GABRB2 | |
| SCHEMBL1437176 | 0.85 | MDM2 (0.90) | MDM2NOTUMPIN1RIPK1KDM4E | |
| SCHEMBL27862830 | 0.84 | MDM2 (0.61) | MDM2NOTUMRIPK1CTSAHTT | |
| SCHEMBL9893679 | 0.84 | MDM2 (0.79) | MDM2NOTUMPIN1RIPK1PKM | |
| SCHEMBL9893724 | 0.83 | MDM2 (1.00) | MDM2NOTUMRIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102574785-A | Tetra-substituted heteroaryl compounds and their use as MDM2 and/or MDM4 modulators | NOVARTIS AG | 2012-07-11 | — | — | CN | disclosed |