Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 13/20 | 0.53 |
| ▸ | PPARD | Q03181 | 3/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.35 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2773502 | 0.94 | NR1H4 (0.54) | NR1H4PPARDNPC1RAB9AMAOB | |
| SCHEMBL2771180 | 0.91 | NR1H4 (0.63) | NR1H4MRGPRX4 | |
| SCHEMBL2770584 | 0.88 | NR1H4 (0.54) | NR1H4MRGPRX4CYP4F2CYP4A11 | |
| SCHEMBL2773707 | 0.88 | NR1H4 (0.60) | NR1H4MRGPRX4 | |
| SCHEMBL2771866 | 0.87 | NR1H4 (0.51) | NR1H4PPARDNPC1RAB9AKMT2A | |
| SCHEMBL2772681 | 0.87 | NR1H4 (0.52) | NR1H4MRGPRX4NPC1RAB9AMAOB | |
| SCHEMBL2771344 | 0.86 | NR1H4 (0.51) | NR1H4MRGPRX4 | |
| SCHEMBL2788930 | 0.86 | NR1H4 (0.52) | NR1H4PPARDMRGPRX4NPC1RAB9A | |
| SCHEMBL2774998 | 0.86 | NR1H4 (0.55) | NR1H4PPARDMRGPRX4CYP4F2CYP4A11 | |
| SCHEMBL2770943 | 0.86 | NR1H4 (0.52) | NR1H4MRGPRX4CYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029547-B1 | FXR AGONISTS | LILLY CO ELI (US) | 2010-04-28 | — | — | EP | disclosed |