Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 6/20 | 0.57 |
| ▸ | CCND1 | P24385 | 6/20 | 0.57 |
| ▸ | CCND3 | P30281 | 5/20 | 0.57 |
| ▸ | CDK6 | Q00534 | 5/20 | 0.57 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.51 |
| ▸ | CDK2 | P24941 | 3/20 | 0.51 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.51 |
| ▸ | CDK1 | P06493 | 3/20 | 0.51 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.51 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.31 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.31 |
| ▸ | PLK1 | P53350 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 2/20 | 0.31 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.30 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27880987 | 0.85 | CDK4 (0.52) | CDK4CCND1CCND3CDK6CCNA2 | |
| SCHEMBL111573 | 0.84 | CDK4 (0.80) | CDK4CCND1CCND3CDK6CCNA2 | |
| SCHEMBL111309 | 0.83 | CDK4 (0.61) | CDK4CCND1CCND3CDK6CCNA2 | |
| SCHEMBL27880988 | 0.83 | CDK4 (0.39) | CDK4CCND1CCND3CDK6CCNA2 | |
| SCHEMBL27897994 | 0.82 | CDK4 (0.37) | CDK4CCND1CCND3CDK6CCNA2 | |
| SCHEMBL108815 | 0.81 | CDK4 (0.61) | CDK4CCND1CCND3CDK6CCNA2 | |
| SCHEMBL111803 | 0.79 | CDK4 (0.80) | CDK4CCND1CCND3CDK6CCNA2 | |
| SCHEMBL31060547 | 0.79 | CDK4 (0.80) | CDK4CCND1CCND3CDK6CCNA2 | |
| SCHEMBL111482 | 0.78 | CDK4 (0.65) | CDK4CCND1CCND3CDK6CCNA2 | |
| SCHEMBL27880989 | 0.78 | CDK4 (0.36) | CDK4CCND1CCND3CDK6CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102803225-A | Imidazole derivatives and their use as modulators of cyclin dependent kinases | NOVARTIS AG | 2012-11-28 | — | — | CN | claimed |
| CN-102803225-A | Imidazole derivatives and their use as modulators of cyclin dependent kinases | NOVARTIS AG | 2012-11-28 | — | — | CN | disclosed |