Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 15/20 | 0.46 |
| ▸ | IKZF3 | Q9UKT9 | 15/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | TNF | P01375 | 5/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 4/20 | 0.39 |
| ▸ | IL1B | P01584 | 3/20 | 0.39 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27881819 | 0.84 | CRBN (0.45) | CRBNIKZF3HDAC3HDAC1TNF | |
| SCHEMBL27899046 | 0.84 | CRBN (0.41) | CRBNIKZF3HDAC3HDAC1TNF | |
| SCHEMBL27899077 | 0.83 | CRBN (0.43) | CRBNIKZF3HDAC3HDAC1TNF | |
| SCHEMBL27899056 | 0.83 | CRBN (0.49) | CRBNIKZF3TNFDDB1IL1B | |
| SCHEMBL27899028 | 0.83 | CRBN (0.51) | CRBNIKZF3TNFDDB1IL1B | |
| SCHEMBL28799815 | 0.83 | CRBN (0.44) | CRBNIKZF3HDAC3HDAC1TNF | |
| SCHEMBL28839156 | 0.82 | CRBN (0.62) | CRBNIKZF3TNFDDB1IL1B | |
| Thiomorpholine SCHEMBL27881774 | 0.80 | CRBN (0.42) | CRBNIKZF3HDAC3HDAC1TNF | |
| SCHEMBL27626192 | 0.80 | CRBN (0.49) | CRBNIKZF3HDAC3HDAC1TNF | |
| SCHEMBL27899132 | 0.80 | CRBN (0.41) | CRBNIKZF3HDAC3HDAC1TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102822165-A | Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same | CELGENE CORP | 2012-12-12 | — | — | CN | disclosed |