Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 5/20 | 0.53 |
| ▸ | TP53 | P04637 | 4/20 | 0.53 |
| ▸ | THRB | P10828 | 3/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL692754 | 0.86 | NPC1 (0.56) | NPC1RAB9ALMNATP53THRB | |
| SCHEMBL20444412 | 0.78 | MEN1 (0.69) | NPC1RAB9AMEN1GAAKMT2A | |
| SCHEMBL692541 | 0.77 | NPC1 (0.53) | NPC1RAB9AMEN1KMT2ALMNA | |
| SCHEMBL19132170 | 0.76 | PTPN2 (0.63) | NPC1RAB9AMEN1GAAKMT2A | |
| SCHEMBL9478963 | 0.76 | MEN1 (0.82) | MEN1GAAKMT2ALMNATHRB | |
| SCHEMBL14877794 | 0.74 | CA12 (0.76) | MEN1GAAKMT2ALMNATHRB | |
| SCHEMBL4665854 | 0.74 | BACE1 (0.60) | MEN1GAAKMT2ALMNATP53 | |
| SCHEMBL1952693 | 0.73 | KMT2A (1.00) | MEN1GAAKMT2ALMNACA12 | |
| SCHEMBL92717 | 0.73 | KMT2A (1.00) | MEN1GAAKMT2ALMNACA12 | |
| SCHEMBL9479370 | 0.73 | KMT2A (1.00) | MEN1GAAKMT2ALMNACA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103068390-A | Compounds, compositions, and methods comprising pyridazine sulfonamide derivatives | INST ONEWORLD HEALTH | 2013-04-24 | — | — | CN | claimed |