SCHEMBL27901705

SCHEMBL27901705

NCc1cc(Br)cc(Nc2nccc(C(F)(F)F)n2)c1

nearest known ligand 0.61

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SYK P43405 19/20 0.61
LOXL2 Q9Y4K0 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2016999 0.89 SYK (0.65) SYK
SCHEMBL2498437 0.85 SYK (0.53) SYK
SCHEMBL16876078 0.83 SYK (0.58) SYK
SCHEMBL2045722 0.82 SYK (0.60) SYK
SCHEMBL27901593 0.81 SYK (0.60) SYK
SCHEMBL1982466 0.81 SYK (0.61) SYK
SCHEMBL16200899 0.81 SYK (0.58) SYK
SCHEMBL2505770 0.80 SYK (0.62) SYK
SCHEMBL27901656 0.80 SYK (0.39) SYKLOXL2
SCHEMBL2014905 0.79 SYK (0.56) SYK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102858767-A Aminopyrimidines as SYK inhibitors MERCK SHARP & DOHME 2013-01-02 CN disclosed