Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 20/20 | 1.00 |
| ▸ | PDE2A | O00408 | 17/20 | 1.00 |
| ▸ | PDE11A | Q9HCR9 | 3/20 | 0.58 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.57 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.57 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.57 |
| ▸ | PDE5A | O76074 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2790365 | 0.89 | PDE10A (0.80) | PDE10APDE2APDE11APDE7AADORA2A | |
| SCHEMBL2789790 | 0.86 | PDE10A (0.76) | PDE10APDE2APDE11APDE7AADORA2A | |
| SCHEMBL970252 | 0.86 | PDE10A (1.00) | PDE10APDE2APDE11APDE7AADORA2A | |
| SCHEMBL2789805 | 0.85 | PDE10A (1.00) | PDE10APDE2APDE11APDE7AADORA2A | |
| SCHEMBL2792240 | 0.84 | PDE10A (0.72) | PDE10APDE2APDE11APDE7AADORA2A | |
| SCHEMBL2790378 | 0.83 | PDE10A (0.71) | PDE10APDE2APDE11APDE7AADORA2A | |
| SCHEMBL2792285 | 0.83 | PDE10A (1.00) | PDE10APDE2APDE11APDE7AADORA2A | |
| SCHEMBL973179 | 0.81 | PDE10A (1.00) | PDE10APDE2APDE11APDE7AADORA2A | |
| SCHEMBL2791004 | 0.80 | PDE10A (0.67) | PDE10APDE2APDE11APDE7AADORA2A | |
| SCHEMBL2789775 | 0.79 | PDE10A (0.79) | PDE10APDE2APDE11APDE7AADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010138833-A1 | SUBSTITUTED IMIDAZO[1,5-a]QUINOXALINES AS INHIBITORS OF PHOSPHODIESTERASE 10 | WYETH (US) | 2010-12-02 | — | — | WO | claimed |
| WO-2010138833-A1 | SUBSTITUTED IMIDAZO[1,5-a]QUINOXALINES AS INHIBITORS OF PHOSPHODIESTERASE 10 | WYETH (US) | 2010-12-02 | — | — | WO | disclosed |