Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PADI4 | Q9UM07 | 3/20 | 0.41 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | PROKR1 | Q8TCW9 | 5/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.36 |
| ▸ | ACE | P12821 | 1/20 | 0.35 |
| ▸ | CMA1 | P23946 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7897490 | 0.92 | PADI4 (0.41) | PADI4KLK5HRH2HRH1PROKR1 | |
| SCHEMBL7891183 | 0.91 | PADI4 (0.40) | PADI4KLK5HRH2HRH1PROKR1 | |
| SCHEMBL739547 | 0.88 | HRH1 (0.41) | PADI4KLK5HRH2HRH1PTGER4 | |
| SCHEMBL739548 | 0.88 | HRH1 (0.41) | PADI4KLK5HRH2HRH1PTGER4 | |
| SCHEMBL7897738 | 0.86 | PADI4 (0.37) | PADI4KLK5HRH2HRH1PROKR1 | |
| SCHEMBL2791389 | 0.85 | CNR2 (0.40) | PADI4PROKR1CNR2PTGER4 | |
| SCHEMBL763858 | 0.84 | KCNH2 (0.42) | KLK5HRH2HRH1ACE | |
| SCHEMBL739119 | 0.83 | HRH1 (0.39) | HRH2HRH1 | |
| SCHEMBL739120 | 0.83 | HRH1 (0.39) | HRH2HRH1 | |
| SCHEMBL2791612 | 0.83 | PROKR1 (0.39) | PADI4PROKR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |