Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Metaxon. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | PPARD | Q03181 | 3/20 | 0.53 |
| ▸ | PPARG | P37231 | 1/20 | 0.53 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 2,4-Dichlorophenoxyacetic Acid SCHEMBL15229221 | 0.88 | TDP1 (0.73) | NPSR1TDP1MAPTTSHRSMN1; SMN2 | |
| Metaxon SCHEMBL117877 | 0.87 | TDP1 (0.70) | NPSR1TDP1MAPTTSHRLMNA | |
| Metaxon SCHEMBL18221951 | 0.86 | TDP1 (0.68) | NPSR1TDP1MAPTTSHRLMNA | |
| Metaxon SCHEMBL27765431 | 0.86 | TDP1 (0.68) | NPSR1TDP1MAPTTSHRLMNA | |
| Metaxon SCHEMBL28800416 | 0.86 | TDP1 (0.68) | NPSR1TDP1MAPTTSHRLMNA | |
| Metaxon SCHEMBL3533162 | 0.86 | TDP1 (0.68) | NPSR1TDP1MAPTTSHRLMNA | |
| Metaxon SCHEMBL27616565 | 0.86 | TDP1 (0.68) | NPSR1TDP1MAPTTSHRLMNA | |
| Metaxon SCHEMBL29384206 | 0.85 | TDP1 (0.59) | NPSR1TDP1MAPTTSHRLMNA | |
| Metaxon SCHEMBL4880562 | 0.83 | TDP1 (0.75) | NPSR1TDP1MAPTTSHRLMNA | |
| Metaxon SCHEMBL27542877 | 0.83 | TDP1 (0.64) | NPSR1TDP1MAPTTSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102835395-A | Preparation method of MCPA (2-methyl-4-chloro-phenoxyacetic acid) choline water aqua and raw drug | SHANDONG WEIFANG RAINBOW CHEM | 2012-12-26 | — | — | CN | disclosed |
| CN-102835395-A | Preparation method of MCPA (2-methyl-4-chloro-phenoxyacetic acid) choline water aqua and raw drug | SHANDONG WEIFANG RAINBOW CHEM | 2012-12-26 | — | — | CN | disclosed |