Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.76 |
| ▸ | JAK2 | O60674 | 12/20 | 0.55 |
| ▸ | JAK1 | P23458 | 8/20 | 0.47 |
| ▸ | JAK3 | P52333 | 3/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2772932 | 0.87 | MAP3K5 (1.00) | MAP3K5JAK2JAK1 | |
| SCHEMBL2790312 | 0.87 | MAP3K5 (0.65) | MAP3K5JAK2JAK1JAK3 | |
| SCHEMBL2787002 | 0.86 | MAP3K5 (0.89) | MAP3K5JAK2JAK1TYK2 | |
| SCHEMBL2788527 | 0.85 | MAP3K5 (0.73) | MAP3K5JAK2JAK1JAK3 | |
| SCHEMBL2789856 | 0.84 | MAP3K5 (0.71) | MAP3K5JAK2JAK1JAK3 | |
| SCHEMBL2788079 | 0.83 | MAP3K5 (0.85) | MAP3K5JAK2JAK1 | |
| SCHEMBL2788369 | 0.83 | MAP3K5 (0.83) | MAP3K5JAK2JAK1TYK2 | |
| SCHEMBL3013739 | 0.83 | MAP3K5 (0.69) | MAP3K5JAK2JAK1JAK3 | |
| SCHEMBL2787590 | 0.82 | MAP3K5 (0.78) | MAP3K5JAK2JAK1JAK3 | |
| SCHEMBL2787856 | 0.81 | MAP3K5 (0.77) | MAP3K5JAK2JAK1JAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2181112-A1 | TRIAZOLOPYRIDINE COMPOUNDS AND THEIR USE AS ASK INHIBITORS | Merck Serono S.A. (CH) | 2010-05-05 | — | — | EP | disclosed |
| WO-2009027283-A1 | TRIAZOLOPYRIDINE COMPOUNDS AND THEIR USE AS ASK INHIBITORS | MERCK SERONO S.A. (CH) | 2009-03-05 | — | — | WO | disclosed |