Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 15/20 | 0.74 |
| ▸ | SSTR2 | P30874 | 4/20 | 0.43 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27907412 | 0.93 | MELK (0.65) | MELKSSTR2SSTR4KCNH2CES2 | |
| SCHEMBL27907374 | 0.87 | MELK (0.76) | MELKSSTR2SSTR4KCNH2CES2 | |
| SCHEMBL27907411 | 0.85 | MELK (0.55) | MELKSSTR2SSTR4KCNH2 | |
| SCHEMBL15190984 | 0.85 | MELK (1.00) | MELK | |
| SCHEMBL27907350 | 0.85 | MELK (0.55) | MELKSSTR2SSTR4KCNH2 | |
| SCHEMBL17434940 | 0.81 | MELK (0.77) | MELKSSTR2 | |
| SCHEMBL27925358 | 0.80 | MELK (0.65) | MELKSSTR2SSTR4KCNH2CES2 | |
| SCHEMBL12505073 | 0.79 | MELK (0.87) | MELK | |
| SCHEMBL528824 | 0.78 | MELK (0.69) | MELKCES2 | |
| SCHEMBL15197673 | 0.78 | MELK (0.78) | MELK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103153063-A | Quinoline derivatives and MELK inhibitors containing the same | ONCOTHERAPY SCIENCE INC | 2013-06-12 | — | — | CN | disclosed |