Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 16/20 | 0.49 |
| ▸ | JAK1 | P23458 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL531021 | 0.86 | MELK (0.62) | MELKJAK1 | |
| SCHEMBL529490 | 0.81 | MELK (0.44) | MELKJAK1JAK2JAK3LMNA | |
| SCHEMBL529446 | 0.80 | MELK (0.75) | MELK | |
| SCHEMBL27925385 | 0.75 | MELK (0.76) | MELKSSTR2 | |
| SCHEMBL27907384 | 0.75 | MELK (0.66) | MELK | |
| SCHEMBL27925443 | 0.71 | MELK (0.75) | MELK | |
| SCHEMBL15190823 | 0.70 | MELK (0.80) | MELK | |
| SCHEMBL27907374 | 0.70 | MELK (0.76) | MELKSSTR2 | |
| SCHEMBL15190916 | 0.69 | MELK (0.81) | MELK | |
| SCHEMBL530446 | 0.68 | MELK (0.89) | MELK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103153063-A | Quinoline derivatives and MELK inhibitors containing the same | ONCOTHERAPY SCIENCE INC | 2013-06-12 | — | — | CN | disclosed |