Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 9/20 | 0.46 |
| ▸ | MAOB | P27338 | 5/20 | 0.46 |
| ▸ | MAOA | P21397 | 4/20 | 0.46 |
| ▸ | TLR2 | O60603 | 1/20 | 0.42 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27991097 | 0.87 | KDM1A (0.54) | KDM1AMAOBMAOA | |
| SCHEMBL27908354 | 0.87 | KDM1A (0.41) | KDM1AMAOBMAOASMN1; SMN2NPSR1 | |
| SCHEMBL2215854 | 0.86 | KDM1A (0.43) | KDM1AMAOBMAOATLR2TLR1 | |
| SCHEMBL27898196 | 0.86 | KDM1A (0.40) | KDM1AMAOBMAOASMN1; SMN2NPSR1 | |
| SCHEMBL27898192 | 0.84 | KDM1A (0.40) | KDM1AMAOBMAOATLR2TLR1 | |
| SCHEMBL27903859 | 0.83 | KDM1A (0.35) | KDM1AMAOBMAOASLC6A4SLC6A3 | |
| SCHEMBL27915792 | 0.81 | NPC1 (0.49) | KDM1AMAOBMAOASMN1; SMN2 | |
| SCHEMBL27891316 | 0.79 | MAOB (0.59) | KDM1AMAOBMAOANPSR1 | |
| SCHEMBL28815307 | 0.76 | KDM1A (0.56) | KDM1AMAOBMAOA | |
| SCHEMBL27974188 | 0.76 | KDM1A (0.45) | KDM1AMAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102639496-B | Lysine specific demethylase-1 inhibitors and their use | ORYZON GENOMICS, S.A. (ES) | 2014-10-29 | — | — | CN | disclosed |
| CN-103958474-A | (hetero) arylcyclopropylamine compounds as LSD1 inhibitors | ORYZON GENOMICS SA | 2014-07-30 | — | — | CN | disclosed |
| CN-103124724-A | Arylcyclopropylamine-based demethylase inhibitors of LSD1 and their medical use | ORYZON GENOMICS SA | 2013-05-29 | — | — | CN | disclosed |
| CN-102947265-A | Lysine specific demethylase-1 inhibitors and their use | ORYZON GENOMICS SA | 2013-02-27 | — | — | CN | disclosed |