Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR3 | Q9UBY5 | 13/20 | 0.94 |
| ▸ | LPAR1 | Q92633 | 12/20 | 0.94 |
| ▸ | LPAR2 | Q9HBW0 | 8/20 | 0.68 |
| ▸ | LPAR5 | Q9H1C0 | 6/20 | 0.66 |
| ▸ | LPAR6 | P43657 | 5/20 | 0.56 |
| ▸ | LPAR4 | Q99677 | 5/20 | 0.56 |
| ▸ | ENPP2 | Q13822 | 5/20 | 0.49 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alcohol SCHEMBL28054641 | 0.98 | LPAR3 (0.91) | LPAR3LPAR1LPAR2LPAR5LPAR6 | |
| SCHEMBL31198159 | 0.97 | LPAR3 (1.00) | LPAR3LPAR1LPAR2LPAR5LPAR6 | |
| SCHEMBL29353224 | 0.97 | LPAR3 (1.00) | LPAR3LPAR1LPAR2LPAR5LPAR6 | |
| SCHEMBL29458233 | 0.97 | LPAR3 (1.00) | LPAR3LPAR1LPAR2LPAR5LPAR6 | |
| SCHEMBL496845 | 0.97 | LPAR3 (1.00) | LPAR3LPAR1LPAR2LPAR5LPAR6 | |
| SCHEMBL2813163 | 0.97 | LPAR3 (1.00) | LPAR3LPAR1LPAR2LPAR5LPAR6 | |
| SCHEMBL2814732 | 0.97 | LPAR3 (1.00) | LPAR3LPAR1LPAR2LPAR5LPAR6 | |
| SCHEMBL5055004 | 0.97 | LPAR3 (1.00) | LPAR3LPAR1LPAR2LPAR5LPAR6 | |
| SCHEMBL30443866 | 0.97 | LPAR3 (1.00) | LPAR3LPAR1LPAR2LPAR5LPAR6 | |
| SCHEMBL10896195 | 0.97 | LPAR3 (1.00) | LPAR3LPAR1LPAR2LPAR5LPAR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109906090-A | Novel lipide gadolinium (Gd) contrast agent \" NMRX \" for T1-MRI | 德克萨斯州儿童医院 | 2019-06-18 | — | — | CN | claimed |
| CN-109745561-A | A kind of HIFU biological targeting synergist and preparation method thereof | 重庆医科大学 | 2019-05-14 | — | — | CN | claimed |
| CN-109414377-A | The Antimicrobial Lipids body composition of the conjugate of lipid derivate containing phaeophorbide A and polyethylene glycol | H&A帕玛科株式会社 | 2019-03-01 | — | — | CN | claimed |
| CN-109152830-A | core/shell structure platform for immunotherapy | 卫理公会医院 | 2019-01-04 | — | — | CN | claimed |
| CN-108472246-A | Colloidal solid for being used in drug | 剑桥生物制药专利有限公司 | 2018-08-31 | — | — | CN | claimed |
| CN-108430457-A | The nano liposomes and preparation method thereof comprising corticosteroid as drug | 南洋理工大学 | 2018-08-21 | — | — | CN | claimed |
| CN-103394102-B | Lipid micro/nano bubble, and optimized preparation method and preparation device thereof | 博信生物科技股份有限公司 | 2018-08-07 | — | — | CN | claimed |
| CN-107847457-A | Method for preparing supramolecular platinum-based compounds | 阿卡马拉医疗公司 | 2018-03-27 | — | — | CN | claimed |
| CN-107106708-A | MRI Imaging of Amyloid Plaques Using Liposomes | 德克萨斯州儿童医院 | 2017-08-29 | — | — | CN | claimed |
| CN-107001031-A | Nanoparticles for photodynamic therapy, X-ray induced photodynamic therapy, radiotherapy, chemotherapy, immunotherapy and any combination thereof | 芝加哥大学 | 2017-08-01 | — | — | CN | claimed |
| CN-109906090-A | Novel lipide gadolinium (Gd) contrast agent \" NMRX \" for T1-MRI | 德克萨斯州儿童医院 | 2019-06-18 | — | — | CN | disclosed |
| CN-109789212-A | Polyglutamated antifolate agent and its use | L.E.A.F.控股集团公司 | 2019-05-21 | — | — | CN | disclosed |
| CN-109745561-A | A kind of HIFU biological targeting synergist and preparation method thereof | 重庆医科大学 | 2019-05-14 | — | — | CN | disclosed |
| CN-109689104-A | α and γ-D polyglutamic is acidified antifol and application thereof | L.E.A.F.控股集团公司 | 2019-04-26 | — | — | CN | disclosed |
| CN-109414377-A | The Antimicrobial Lipids body composition of the conjugate of lipid derivate containing phaeophorbide A and polyethylene glycol | H&A帕玛科株式会社 | 2019-03-01 | — | — | CN | disclosed |
| CN-107427531-A | Lipid nanoparticle containing nucleic acid | 协和发酵麒麟株式会社 | 2017-12-01 | — | — | CN | disclosed |
| CN-106458884-A | Cationic lipid | 协和发酵麒麟株式会社 | 2017-02-22 | — | — | CN | disclosed |
| CN-106008272-A | Cationic lipid | 协和发酵麒麟株式会社 | 2016-10-12 | — | — | CN | disclosed |
| CN-105705152-A | Lipid-based platinum compounds and nanoparticles | 成事在人肿瘤学公司 | 2016-06-22 | — | — | CN | disclosed |
| CN-101374955-B | Targeting vector-phospholipid conjugates | BRACCO INT BV | 2013-03-27 | — | — | CN | disclosed |