Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 3/20 | 0.49 |
| ▸ | INSR | P06213 | 1/20 | 0.48 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.48 |
| ▸ | STAT6 | P42226 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 2/20 | 0.45 |
| ▸ | CDK2 | P24941 | 2/20 | 0.45 |
| ▸ | CDK4 | P11802 | 1/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.45 |
| ▸ | CCND3 | P30281 | 1/20 | 0.45 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11028611 | 0.87 | SLC2A1 (0.51) | SLC2A1INSRALKSTAT6EGFR | |
| SCHEMBL11033766 | 0.87 | SLC2A1 (0.51) | SLC2A1INSRALKSTAT6EGFR | |
| SCHEMBL11031519 | 0.87 | SLC2A1 (0.57) | SLC2A1INSRALKEGFRMAPKAPK2 | |
| SCHEMBL11029599 | 0.86 | MAPKAPK2 (0.58) | SLC2A1INSRALKSTAT6EGFR | |
| SCHEMBL11030017 | 0.85 | STAT6 (0.48) | SLC2A1INSRALKSTAT6EGFR | |
| SCHEMBL11033969 | 0.84 | SLC2A1 (0.56) | SLC2A1INSRALKSTAT6EGFR | |
| SCHEMBL11028125 | 0.83 | ALK (0.56) | SLC2A1INSRALKSTAT6EGFR | |
| SCHEMBL11026741 | 0.82 | FYN (0.55) | SLC2A1EGFRMAPKAPK2AURKACDK2 | |
| SCHEMBL11029346 | 0.82 | MAPKAPK2 (0.61) | SLC2A1INSRALKEGFRMAPKAPK2 | |
| SCHEMBL11031445 | 0.82 | SLC2A1 (0.51) | SLC2A1EGFRMAPKAPK2PTK2AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103380117-A | Picolinamide inhibitors of kinases | ABBOTT LAB | 2013-10-30 | — | — | CN | claimed |
| CN-103380117-A | Picolinamide inhibitors of kinases | ABBOTT LAB | 2013-10-30 | — | — | CN | disclosed |