Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR3 | Q9UBY5 | 13/20 | 0.81 |
| ▸ | LPAR2 | Q9HBW0 | 9/20 | 0.81 |
| ▸ | LPAR1 | Q92633 | 6/20 | 0.81 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.51 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphoric Acid Monotetradecyl Ester SCHEMBL28957513 | 0.98 | LPAR3 (0.78) | LPAR3LPAR2LPAR1LPAR5SMPD1 | |
| Methylamine SCHEMBL27483750 | 0.90 | LPAR3 (0.91) | LPAR3LPAR2LPAR1LPAR5SMPD1 | |
| Phosphoric Acid Monododecyl Ester SCHEMBL9316956 | 0.90 | LPAR3 (1.00) | LPAR3LPAR2LPAR1LPAR5SMPD1 | |
| Hexadecyl Dihydrogen Phosphate SCHEMBL63748 | 0.90 | LPAR3 (1.00) | LPAR3LPAR2LPAR1LPAR5SMPD1 | |
| Phosphoric Acid Monodecyl Ester SCHEMBL597742 | 0.90 | LPAR3 (1.00) | LPAR3LPAR2LPAR1LPAR5SMPD1 | |
| SCHEMBL1923668 | 0.90 | LPAR3 (1.00) | LPAR3LPAR2LPAR1LPAR5SMPD1 | |
| SCHEMBL29136 | 0.90 | LPAR3 (1.00) | LPAR3LPAR2LPAR1LPAR5SMPD1 | |
| Phosphoric Acid Monododecyl Ester SCHEMBL9437045 | 0.90 | LPAR3 (1.00) | LPAR3LPAR2LPAR1LPAR5SMPD1 | |
| SCHEMBL22325599 | 0.90 | LPAR3 (1.00) | LPAR3LPAR2LPAR1LPAR5SMPD1 | |
| SCHEMBL118839 | 0.90 | LPAR3 (1.00) | LPAR3LPAR2LPAR1LPAR5SMPD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105658055-A | Antimicrobial compositions | 利拉伐控股有限公司 | 2016-06-08 | — | — | CN | disclosed |
| CN-103145981-B | Polyhexamethylene guanidine phosphate and synthetic method thereof | SHANGHAI HIPOLY BIOTECHNOLOGY LTD | 2015-04-01 | — | — | CN | disclosed |
| CN-103145981-A | Polyhexamethylene guanidine phosphate and synthetic method thereof | SHANGHAI GAOJU BIOTECHNOLOGY CO LTD | 2013-06-12 | — | — | CN | disclosed |