Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 20/20 | 0.87 |
| ▸ | PDE10A | Q9Y233 | 20/20 | 0.87 |
| ▸ | PDE6D | O43924 | 3/20 | 0.68 |
| ▸ | PDE6A | P16499 | 3/20 | 0.68 |
| ▸ | PDE6G | P18545 | 3/20 | 0.68 |
| ▸ | PDE6B | P35913 | 3/20 | 0.68 |
| ▸ | PDE6C | P51160 | 3/20 | 0.68 |
| ▸ | PDE6H | Q13956 | 3/20 | 0.68 |
| ▸ | PDE11A | Q9HCR9 | 3/20 | 0.67 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.66 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.66 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.57 |
| ▸ | PDE5A | O76074 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2791914 | 0.91 | PDE2A (0.81) | PDE2APDE10APDE6DPDE6APDE6G | |
| SCHEMBL2844580 | 0.86 | PDE2A (0.69) | PDE2APDE10APDE6DPDE6APDE6G | |
| SCHEMBL2840425 | 0.85 | PDE10A (0.85) | PDE2APDE10APDE6DPDE6APDE6G | |
| SCHEMBL2792231 | 0.83 | PDE10A (0.66) | PDE2APDE10APDE6DPDE6APDE6G | |
| SCHEMBL2791125 | 0.83 | PDE10A (0.81) | PDE2APDE10APDE6DPDE6APDE6G | |
| SCHEMBL3329216 | 0.81 | PDE2A (1.00) | PDE2APDE10APDE6DPDE6APDE6G | |
| SCHEMBL972290 | 0.80 | PDE2A (1.00) | PDE2APDE10APDE6DPDE6APDE6G | |
| SCHEMBL973300 | 0.79 | PDE10A (1.00) | PDE2APDE10APDE11AADORA2AADORA1 | |
| SCHEMBL7808426 | 0.79 | PDE10A (1.00) | PDE2APDE10APDE6DPDE6APDE6G | |
| SCHEMBL2789807 | 0.76 | PDE10A (0.77) | PDE2APDE10APDE6DPDE6APDE6G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010138833-A1 | SUBSTITUTED IMIDAZO[1,5-a]QUINOXALINES AS INHIBITORS OF PHOSPHODIESTERASE 10 | WYETH (US) | 2010-12-02 | — | — | WO | claimed |