Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.58 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.58 |
| ▸ | CHEK2 | O96017 | 14/20 | 0.51 |
| ▸ | FYN | P06241 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 5/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2377871 | 0.74 | FYN (0.40) | CHEK2FYNMAP4K4 | |
| SCHEMBL183005 | 0.73 | MKNK1 (0.44) | MKNK1MKNK2CHEK2FYNMAP4K4 | |
| SCHEMBL12516852 | 0.72 | CHEK2 (0.88) | MKNK1CHEK2FYNMAP4K4CHEK1 | |
| SCHEMBL2228006 | 0.72 | CHEK2 (0.75) | MKNK1CHEK2FYNMAP4K4CHEK1 | |
| SCHEMBL12516834 | 0.70 | FYN (0.69) | MKNK1MKNK2CHEK2FYNMAP4K4 | |
| SCHEMBL1091006 | 0.70 | MAP4K4 (0.76) | MKNK1MKNK2CHEK2FYNMAP4K4 | |
| SCHEMBL3724186 | 0.68 | MKNK2 (0.54) | MKNK1MKNK2CHEK2FYNMAP4K4 | |
| SCHEMBL4620246 | 0.68 | CHEK2 (1.00) | MKNK1CHEK2FYNMAP4K4CHEK1 | |
| SCHEMBL12079344 | 0.68 | CHEK2 (0.62) | MKNK1MKNK2CHEK2FYNMAP4K4 | |
| SCHEMBL18613241 | 0.68 | FYN (1.00) | MKNK1CHEK2FYNMAP4K4CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103429582-A | MST1 kinase inhibitors and method of use thereof | LEXICON PHARMACEUTICALS INC | 2013-12-04 | — | — | CN | disclosed |