Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 11/20 | 0.43 |
| ▸ | PRKDC | P78527 | 5/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27951095 | 1.00 | P2RY12 (0.44) | P2RY12PIK3CBPRKDCPIK3CDPIK3CA | |
| SCHEMBL17424923 | 0.83 | PIK3CB (0.49) | P2RY12PIK3CBPRKDCPIK3CDPIK3CA | |
| SCHEMBL13276470 | 0.83 | PIK3CB (0.49) | P2RY12PIK3CBPRKDCPIK3CDPIK3CA | |
| SCHEMBL13276708 | 0.83 | PIK3CB (0.49) | P2RY12PIK3CBPRKDCPIK3CDPIK3CA | |
| SCHEMBL13276778 | 0.81 | PIK3CB (0.64) | PIK3CBPIK3CDPIK3CAPIK3CGKCNH2 | |
| SCHEMBL13449189 | 0.81 | PIK3CB (0.55) | PIK3CBPIK3CDPIK3CAPIK3CGMTOR | |
| SCHEMBL13277055 | 0.81 | PIK3CB (0.62) | PIK3CBPIK3CDPIK3CAPIK3CGMTOR | |
| SCHEMBL27951098 | 0.80 | PIK3CB (0.46) | PIK3CBPRKDCPIK3CDPIK3CAPIK3CG | |
| SCHEMBL27937987 | 0.80 | PIK3CB (0.46) | PIK3CBPRKDCPIK3CDPIK3CAPIK3CG | |
| SCHEMBL27889932 | 0.79 | PRKDC (0.55) | P2RY12PRKDCPIK3CDPIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103596948-B | Benzopyranone compounds as PI 3-kinase inhibitors for the treatment of cancer | ASTRAZENECA AB (SE) | 2016-04-27 | — | — | CN | disclosed |
| CN-103596948-A | Benzopyranone compounds as PI 3-kinase inhibitors for the treatment of cancer | ASTRAZENECA AB | 2014-02-19 | — | — | CN | disclosed |