SCHEMBL27938720

SCHEMBL27938720

C=CC(N1CCN(c2cccc(C(F)(F)F)n2)CC1)S(=O)(=O)c1ccc(NC(=O)NCc2cccnc2)cc1

nearest known ligand 0.53

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
NAMPT P43490 20/20 0.53
CYP2C9 P11712 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27920062 0.88 NAMPT (0.57) NAMPT
SCHEMBL27938499 0.87 NAMPT (0.56) NAMPT
SCHEMBL28805763 0.87 NAMPT (0.62) NAMPTCYP2C9
SCHEMBL27938702 0.86 NAMPT (0.55) NAMPTCYP2C9
SCHEMBL27920060 0.86 NAMPT (0.60) NAMPT
SCHEMBL27920067 0.85 NAMPT (0.62) NAMPT
SCHEMBL29635648 0.84 NAMPT (0.70) NAMPTCYP2C9
SCHEMBL165348 0.84 NAMPT (0.70) NAMPTCYP2C9
SCHEMBL27920096 0.84 NAMPT (0.70) NAMPTCYP2C9
SCHEMBL27920078 0.84 NAMPT (0.67) NAMPTCYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103270023-A 4- { [ (pyridin-3-yl-methyl) aminocarbonyl ] amino } benzene-sulfone derivatives as NAMPT inhibitors for the treatment of diseases such as cancer FORMA THERAPEUTICS INC 2013-08-28 CN claimed