SCHEMBL2794351

SCHEMBL2794351

COc1ccc2cc(-c3cc(-c4cc(C(F)(F)F)ccc4OC)nn3C(C)c3ccc(C(=O)NCCC(=O)O)cc3)ccc2c1

nearest known ligand 0.87

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
GCGR P47871 20/20 0.87
GIPR P48546 13/20 0.87
VIPR2 P41587 4/20 0.76
GLP1R P43220 2/20 0.76
KCNH2 Q12809 1/20 0.71
CYP1A2 P05177 1/20 0.70
CYP3A4 P08684 1/20 0.70
CYP2C8 P10632 1/20 0.70
CYP2C9 P11712 1/20 0.70
CYP2B6 P20813 1/20 0.70
VIPR1 P32241 1/20 0.70
DUSP2 Q05923 1/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL928959 1.00 GCGR (0.87) GCGRGIPRVIPR2GLP1RKCNH2
SCHEMBL2642981 0.95 GCGR (0.83) GCGRGIPRVIPR2GLP1RKCNH2
SCHEMBL926751 0.94 GCGR (0.82) GCGRGIPRVIPR2GLP1RKCNH2
SCHEMBL2642936 0.94 GCGR (0.82) GCGRGIPRVIPR2GLP1RKCNH2
SCHEMBL2790901 0.94 GCGR (0.82) GCGRGIPRVIPR2GLP1RKCNH2
SCHEMBL2643058 0.94 GCGR (0.77) GCGRGIPRVIPR2GLP1RKCNH2
SCHEMBL2643626 0.93 GCGR (0.80) GCGRGIPRVIPR2GLP1RKCNH2
SCHEMBL2642984 0.93 GCGR (0.78) GCGRGIPRVIPR2GLP1RKCNH2
SCHEMBL2643172 0.93 GCGR (0.87) GCGRGIPRVIPR2GLP1RKCNH2
SCHEMBL2662897 0.93 GCGR (1.00) GCGRGIPRVIPR2GLP1RKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2259680-A1 SOLUBLE EPOXIDE HYDROLASE INHIBITORS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT Merck Sharp & Dohme Corp. (US) 2010-12-15 EP disclosed
EP-2178534-A1 SOLUBLE EPOXIDE HYDROLASE INHIBITORS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT Merck Sharp & Dohme Corp. (US) 2010-04-28 EP disclosed
WO-2009111207-A1 SOLUBLE EPOXIDE HYDROLASE INHIBITORS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT MERCK & CO., INC. (US) 2009-09-11 WO disclosed
WO-2009011872-A1 SOLUBLE EPOXIDE HYDROLASE INHIBITORS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT MERCK & CO., INC. (US) 2009-01-22 WO disclosed