Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 6/20 | 0.46 |
| ▸ | SYK | P43405 | 2/20 | 0.37 |
| ▸ | JAK1 | P23458 | 5/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2279633 | 0.89 | JAK3 (0.50) | JAK3SYKJAK1JAK2CHRM4 | |
| SCHEMBL2277738 | 0.87 | JAK3 (0.49) | JAK3CHRM4CHRM2 | |
| SCHEMBL2277369 | 0.86 | JAK3 (0.51) | JAK3SYKJAK1JAK2TYK2 | |
| SCHEMBL13689491 | 0.86 | JAK3 (0.52) | JAK3JAK1CHRM4CHRM2CNR2 | |
| SCHEMBL2280391 | 0.85 | JAK3 (0.51) | JAK3JAK1JAK2TYK2CNR2 | |
| SCHEMBL2279247 | 0.85 | JAK3 (0.51) | JAK3SYKJAK1CHRM4CHRM2 | |
| SCHEMBL2277617 | 0.85 | JAK3 (0.49) | JAK3SYKJAK1JAK2TYK2 | |
| SCHEMBL2275248 | 0.84 | JAK3 (0.50) | JAK3JAK1JAK2TYK2 | |
| SCHEMBL2279799 | 0.83 | JAK3 (0.51) | JAK3JAK2 | |
| SCHEMBL2274879 | 0.83 | JAK3 (0.47) | JAK3JAK1JAK2TYK2PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101952295-B | Pyrrolopyrazine kinase inhibitors | HOFFMANN LA ROCHE | 2013-11-20 | — | — | CN | claimed |