Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 9/20 | 0.35 |
| ▸ | JAK3 | P52333 | 9/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 8/20 | 0.35 |
| ▸ | BRD9 | Q9H8M2 | 3/20 | 0.35 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.35 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | SMO | Q99835 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1922133 | 0.90 | BRD9 (0.36) | JAK2JAK3PTK2BRD9KAT2B | |
| SCHEMBL27950046 | 0.89 | JAK2 (0.34) | JAK2JAK3PTK2BRD9CARM1 | |
| SCHEMBL27935549 | 0.88 | JAK2 (0.38) | JAK2JAK3PTK2BRD9CARM1 | |
| SCHEMBL27935548 | 0.87 | CHEK1 (0.36) | JAK2JAK3BRD9KAT2BJAK1 | |
| SCHEMBL27950037 | 0.86 | JAK2 (0.39) | JAK2JAK3PTK2BRD9CARM1 | |
| SCHEMBL303994 | 0.82 | JAK2 (0.37) | JAK2JAK3PTK2BRD9KAT2B | |
| SCHEMBL1921911 | 0.80 | JAK2 (0.37) | JAK2JAK3PTK2BRD9KAT2B | |
| SCHEMBL304368 | 0.79 | JAK2 (0.42) | JAK2JAK3PTK2BRD9CARM1 | |
| SCHEMBL303738 | 0.79 | JAK2 (0.34) | JAK2JAK3PTK2BRD9CARM1 | |
| SCHEMBL305399 | 0.78 | CARM1 (0.39) | JAK2JAK3PTK2BRD9CARM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102203067-B | Hedgehog pathway modulators | IRM LLC | 2014-01-15 | — | — | CN | claimed |
| CN-102203067-B | Hedgehog pathway modulators | IRM LLC | 2014-01-15 | — | — | CN | disclosed |