Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 6/20 | 0.59 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.43 |
| ▸ | CDK11A | Q9UQ88 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 2/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.35 |
| ▸ | VCP | P55072 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27937575 | 0.92 | PDE5A (0.60) | PDE5ACCNT1CDK4CCND1CDK9 | |
| SCHEMBL26647596 | 0.90 | PDE5A (0.58) | PDE5ACCNT1CDK4CCND1CDK9 | |
| SCHEMBL27950964 | 0.90 | PDE5A (0.62) | PDE5ACCNT1CDK4CCND1CDK9 | |
| SCHEMBL291286 | 0.89 | PDE5A (0.77) | PDE5AALDH1A1HPGD | |
| SCHEMBL27950930 | 0.89 | PDE5A (0.61) | PDE5ACCNT1CDK4CCND1CDK9 | |
| SCHEMBL27937605 | 0.89 | PDE5A (0.59) | PDE5ACCNT1CDK4CCND1CDK9 | |
| SCHEMBL27950958 | 0.88 | PDE5A (0.56) | PDE5ACCNT1CDK4CCND1CDK9 | |
| SCHEMBL20559620 | 0.87 | PDE5A (0.76) | PDE5ACCNT1CDK4CCND1CDK9 | |
| SCHEMBL27937611 | 0.87 | PDE5A (0.71) | PDE5AALDH1A1HPGDTDP1 | |
| SCHEMBL20559847 | 0.86 | PDE5A (0.57) | PDE5ACCNT1CDK4CCND1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103547267-A | Treatment of addiction and impulse control disorders using PDE7 inhibitors | OMEROS CORP | 2014-01-29 | — | — | CN | disclosed |