Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.34 |
| ▸ | WNT1 | P04628 | 1/20 | 0.34 |
| ▸ | GBA1 | P04062 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14727588 | 0.84 | CYP3A4 (0.51) | CYP1A2CYP3A4CYP2D6CYP2C19HSD17B10 | |
| SCHEMBL14359014 | 0.80 | CYP1A2 (0.45) | CYP1A2CYP3A4CYP2D6CYP2C19HSD17B10 | |
| SCHEMBL14358686 | 0.80 | CYP3A4 (0.47) | CYP1A2CYP3A4CYP2D6CYP2C19HSD17B10 | |
| SCHEMBL18023040 | 0.80 | CYP3A4 (0.49) | CYP1A2CYP3A4CYP2D6CYP2C19HSD17B10 | |
| SCHEMBL16183577 | 0.79 | CYP1A2 (0.46) | CYP1A2CYP3A4CYP2D6CYP2C19HSD17B10 | |
| SCHEMBL16183493 | 0.79 | CYP1A2 (0.46) | CYP1A2CYP3A4CYP2D6CYP2C19HSD17B10 | |
| SCHEMBL16185009 | 0.79 | PIK3CA (0.43) | CYP1A2CYP3A4CYP2D6CYP2C19HSD17B10 | |
| SCHEMBL16184989 | 0.77 | CYP1A2 (0.46) | CYP1A2CYP3A4CYP2D6CYP2C19HSD17B10 | |
| SCHEMBL16184844 | 0.77 | HSD17B10 (0.43) | CYP1A2CYP3A4CYP2D6CYP2C19HSD17B10 | |
| SCHEMBL14475552 | 0.76 | CYP1A2 (0.51) | CYP1A2CYP3A4CYP2D6CYP2C19HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103703001-A | Quinazolines as therapeutic compounds and related methods of use | OTSUKA PHARMA CO LTD | 2014-04-02 | — | — | CN | disclosed |