Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.33 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.33 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29087328 | 0.96 | TSHR (0.46) | TSHRLMNAKDM4EKMT2AMEN1 | |
| SCHEMBL3447711 | 0.94 | TSHR (0.44) | TSHRLMNAKDM4EKMT2AMEN1 | |
| SCHEMBL14151827 | 0.92 | TSHR (0.50) | TSHRLMNAKDM4EKMT2AMEN1 | |
| SCHEMBL18402675 | 0.83 | TSHR (0.48) | TSHRLMNAKDM4EKMT2AMEN1 | |
| SCHEMBL28207119 | 0.83 | TSHR (0.48) | TSHRLMNAKDM4EKMT2AALDH1A1 | |
| SCHEMBL27623828 | 0.80 | TSHR (0.54) | TSHRLMNAKDM4EKMT2AMEN1 | |
| SCHEMBL23890366 | 0.79 | TSHR (0.41) | TSHRLMNAKDM4EKMT2AMEN1 | |
| SCHEMBL15621351 | 0.79 | TSHR (0.39) | TSHRLMNAKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL8252653 | 0.78 | TSHR (0.48) | TSHRLMNAKDM4EKMT2AMEN1 | |
| SCHEMBL15539095 | 0.77 | TSHR (0.52) | TSHRLMNAKDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105503862-B | Inhibitors of influenza viruses replication | 沃泰克斯药物股份有限公司 | 2018-02-02 | — | — | CN | disclosed |
| CN-105503862-A | Inhibitors of influenza virus replication | VERTEX PHARMA | 2016-04-20 | — | — | CN | disclosed |
| CN-105481853-A | Inhibitors of influenza viruses replication | VERTEX PHARMA | 2016-04-13 | — | — | CN | disclosed |
| CN-103764654-B | Inhibitors of influenza virus replication | VERTEX PHARMACEUTICALS INC. (US) | 2016-01-20 | — | — | CN | disclosed |
| CN-103764654-A | Inhibitors of influenza virus replication | VERTEX PHARMA | 2014-04-30 | — | — | CN | disclosed |