Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.70 |
| ▸ | CTSD | P07339 | 16/20 | 0.70 |
| ▸ | BACE2 | Q9Y5Z0 | 13/20 | 0.70 |
| ▸ | REN | P00797 | 3/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4062952 | 0.87 | BACE1 (0.82) | BACE1CTSDBACE2REN | |
| SCHEMBL2795200 | 0.84 | BACE1 (0.60) | BACE1CTSDBACE2REN | |
| SCHEMBL2793832 | 0.83 | BACE1 (1.00) | BACE1CTSDBACE2REN | |
| SCHEMBL13230584 | 0.82 | BACE1 (0.75) | BACE1CTSDBACE2REN | |
| SCHEMBL4070131 | 0.78 | BACE1 (0.81) | BACE1CTSDBACE2REN | |
| SCHEMBL4065191 | 0.78 | BACE1 (0.81) | BACE1CTSDBACE2REN | |
| SCHEMBL4069674 | 0.78 | BACE1 (0.81) | BACE1CTSDBACE2REN | |
| SCHEMBL4069358 | 0.78 | BACE1 (1.00) | BACE1CTSDBACE2REN | |
| SCHEMBL4063633 | 0.78 | BACE1 (1.00) | BACE1CTSDBACE2REN | |
| SCHEMBL4062702 | 0.78 | BACE1 (1.00) | BACE1CTSDBACE2REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100168091-A1 | Imidazole Amines As Inhibitors Of Beta-secretase | WYETH LLC (US) | 2010-07-01 | — | — | US | claimed |
| US-20080051390-A1 | Imidazole amines as inhibitors of beta-secretase | WYETH (US) | 2008-02-28 | — | — | US | claimed |
| US-20100168091-A1 | Imidazole Amines As Inhibitors Of Beta-secretase | WYETH LLC (US) | 2010-07-01 | — | — | US | disclosed |
| US-7700606-B2 | Imidazole amines as inhibitors of β-secretase | WYETH LLC (US) | 2010-04-20 | — | — | US | disclosed |
| EP-2054414-A2 | IMIDAZOLE AMINES AS INHIBITORS OF BETA-SECRETASE | Wyeth (US) | 2009-05-06 | — | — | EP | disclosed |
| US-20080051390-A1 | Imidazole amines as inhibitors of beta-secretase | WYETH (US) | 2008-02-28 | — | — | US | disclosed |
| WO-2008022024-A2 | IMIDAZOLE AMINES AS INHIBITORS OF BETA-SECRETASE | WYETH (US) | 2008-02-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168091-A1 | Imidazole Amines As Inhibitors Of Beta-secretase | BACE1, BACE2, APP | BACE1 1/4885CTSD 154/4885BACE2 2/4885 |
| US-20080051390-A1 | Imidazole amines as inhibitors of beta-secretase | BACE1, BACE2, APP | BACE1 1/4885CTSD 170/4885BACE2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.